DHEA supplementation lowers cortisol ranges

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In small portions the stress hormone cortisol is amazingly helpful, however constantly raised ranges of it are unhealthy… for almost every little thing. We’ve been performing some digging round in outdated scientific journals, and fortuitously there’s a simple solution to cut back the quantity of cortisol in your physique by thirty to forty p.c. Take 25 mg DHEA every day, and Bob’s your [anticatabolic] uncle.

25 mg DHEA/every day
The cortisol-reducing facet of DHEA supplementation isn’t our personal discovery. A reader despatched us the YouTube clip under, during which Jeff Anderson advises males who wish to lose fats within the chest space to take 25 mg DHEA every day. Fats deposition on this space is partly as a consequence of cortisol, says Anderson, and you’ll cut back your cortisol degree by taking a low dose of DHEA day-after-day.

Research 1
Whether or not males can really lose pec fats by taking DHEA we don’t know, however the concept that DHEA supplementation reduces the cortisol degree holds water. Not less than, we discovered a examine carried out in 2003, during which researchers on the College of Pittsburgh acquired 69-year-old women and men to take 200 mg DHEA day-after-day for 15 days. [J Clin Psychopharmacol. 2003 Feb;23(1):96-9.]

Supplementation began on day 8 and continued till day 22. The bars within the figures under present the quantity of cortisol within the blood of the members on every of these days.

The discount in cortisol degree because of the DHEA was larger within the ladies than within the males. Though the boys’s cortisol ranges did go down, the discount was not statistically vital on all days.

Research 2
A every day dose of 200 mg DHEA is on the excessive facet. Researchers use a dose of fifty mg DHEA per day in most research. In 2006 Italian researchers revealed the outcomes of a examine on the impact of a significantly decrease dose of DHEA on cortisol ranges. [Gynecol Endocrinol. 2006 Nov;22(11):627-35.]

The Italians gave their check topics – ladies aged between 50 and 55 [dark bars on the figure below] and between 60 and 65 [light coloured bars] – a every day 25 mg DHEA for a interval of 12 months. 0 = cortisol degree earlier than DHEA supplementation began; 2 = after 3 months; 3 = after 6 months; 4 = after 12 months.

The determine above reveals how DHEA supplementation may go. It reveals the impact of the administration of 10 micrograms ACTH on the cortisol degree, earlier than administration, and after 3, 6 and 12 months. ACTH is the messenger hormone that stimulates the adrenals to launch cortisol. ACTH secretion will increase beneath stress. It appears that evidently DHEA supplementation makes the adrenals much less delicate to ACTH.

For those who’re pondering of making an attempt to decrease your cortisol degree by taking DHEA, you’ll in all probability discover most impact when you take the prohormone earlier than you fall asleep. Throughout your sleep your DHEA degree will peak. Your cortisol degree may even peak whilst you’re asleep, so inhibiting the cortisol might be best at that second. Sounds logical, doesn’t it?

Lengthy-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal ladies.


The ageing course of is related to a decline within the circulating Delta5-androgen dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS). The current examine aimed to judge the results of a long-term (12 months) oral DHEA administration (25 mg/day) on adrenal perform, earlier than and after 3, 6 and 12 months of remedy.

Postmenopausal ladies belonging to 2 age teams, 50-55 years (n = 10) and 60-65 years (n = 10), have been studied. Adrenal perform was assessed in basal situations, after suppression with dexamethasone (DXM) and following a stimulation check with adrenocorticotropic hormone (ACTH) (10 microg bolus). Serum ranges of DHEA, DHEAS, androstenedione (Delta4-A), allopregnanolone, 17-hydroxyprogesterone (17-OHP) and cortisol have been measured and the results of DHEA supplementation on particular adrenal enzymatic pathways have been evaluated by calculating precursor/product ratios (17-OHP/cortisol, 17-OHP/Delta4-A, DHEA/Delta4-A and DHEA/DHEAS).

DHEA supplementation annulled the age-related variations in DHEA and DHEAS ranges and induced a marked enhance in all steroids, aside from cortisol, after 3-6 months of remedy. Serum cortisol ranges decreased from the third month, each in youthful and older topics. DHEA supplementation didn’t have an effect on DXM-induced suppression of adrenal steroidogenesis. Throughout the remedy interval all adrenal androgens and progestins confirmed a big enhance of their response to ACTH, whereas the cortisol response decreased considerably. The outcomes counsel a big DHEA-induced change in adrenal enzymatic actions, as additionally evidenced by the change in precursor/product ratios throughout remedy.

Power DHEA administration is able to modifying circulating ranges of androgens and progestins in each early and late postmenopausal ladies by modulating the age-related adjustments in adrenal perform.

PMID: 17145649 DOI: 10.1080/09513590601024681 [Indexed for MEDLINE]

Supply: https://www.ncbi.nlm.nih.gov/pubmed/17145649


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